Olfm4 and cancer

Author: qbuz

August undefined, 2024

Web02. maj 2024. · Conclusion: OLFM4 is induced by the LGR5-Wnt signaling pathway and is strongly associated with aggressive tumor progression and poor prognosis in HCC by regulating STAT3-induced tumor cell proliferation and cancer stem cell–like property. Therefore, OLFM4 is a novel prognostic predictor and a potential therapeutic target for … Web29. mar 2024. · circulating OLFM4 could be an interesting biomarker of early breast cancer. high expression of OLFM4 was involved in chemoresistance and was an independent …

National Center for Biotechnology Information

Web08. nov 2024. · Tumor stem cells play a pivotal role in carcinogenesis and metastatic spread in colorectal cancer (CRC). Olfactomedin 4 (OLFM4) is co-expressed with the established stem cell marker leucine-rich repeat-containing G protein-coupled receptor 5 at the bottom of intestinal crypts and has been suggested as a surrogate for cancer stemness and a … WebHuman OLFM4 is expressed in comparable fashion to murine Olfm4 in the small intestine, that is, in crypt base columnar cells (Figure 1A and B). Although murine OlfM4 is not expressed in the colon, a speciﬁc signal was detected in human colonic epithelium (Figure 1C), rem-iniscent of Lgr5 expression in the colon.10 OLFM4 was east boydhaven

Olfactomedin 4 promotes S‐phase transition in proliferation of ...

WebAs a target gene of important signal pathways implicated in cancer and inflammation, OLFM4 may emerge as a potential therapeutic target for these diseases. Recent publications have also reported increased expression of OLFM4 in gastrointestinal cancer ( 10 – 13 ) and inflammatory disease including inflammatory bowel disease ( 14 ) and H ... WebNational Center for Biotechnology Information Web02. maj 2024. · OLFM4 promotes tumor cell proliferation by activating STAT3 and accelerating cell-cycle progression in gastric cancer 22 and pancreatic cancer. 25 … east boynton fl

Olfactomedin 4 deletion induces colon adenocarcinoma in

Olfactomedin 4 associates with expression of differentiation …

Web01. jun 2016. · Development of colorectal cancer (CRC) is regulated by a series of genetic and microenvironmental alterations. Olfactomedin 4 (OLFM4) is a secreted glycoprotein … Web14. mar 2016. · Previous studies have shown that OLFM4 protein expression has been reduced or lost in a portion of human colon cancers, with loss being more prevalent in … east boys shoesWeb10. jan 2007. · Overexpression of the olfactomedin 4 (OLFM4 GW112,/hGC−1) gene was recently reported to inhibit various apoptotic pathways and promote proliferation of … east bowling club

"Web21. mar 2024. · OLFM4 (Olfactomedin 4) is a Protein Coding gene. Diseases associated with OLFM4 include Atrophy Of Prostate and Colonic Benign Neoplasm.Among its … " - Olfm4 and cancer

Olfm4 and cancer

Web10. apr 2024. · Gastric cancer is a dominant source of cancer-related death around the globe and a serious threat to human health. However, there are very few practical diagnostic approaches and biomarkers for the treatment of this complex disease. ... SFRP4, CDH17, FAP, CLDN1, and OLFM4 were of the highest LogFC values among the upregulated … WebOLFM4 expression has been studied in several tumor types including gastric, colorectal, lung, and endometrioid cancers where it has been suggested to be an independent …

Did you know?

Web10. jan 2024. · Chemoresistance was observed by in vitro analysis of tumor cell lines with forced expression of OLFM4. In an assessment of tissue specimens from 80 patients … Web01. mar 2007. · The results indicate that OLFM4 promotes proliferation of PANC‐1 cells by favoring transition from the S to G2/M phase and inhibition of small interfering RNA did not promote apoptosis. Induction of olfactomedin 4 (OLFM4GW112/hGC‐1) in cancer cells was recently reported to have a novel antiapoptotic action via binding to the potent apoptosis …

WebOLFM4 is proved to as a functional target for miR-590. PMID: 28012926; Olfactomedin 4 is a novel tumor marker for triple-negative breast cancer for predicting and prognosis. PMID: 27939521; OLFM4 is downregulated by miR-486-5p, which contributes to … WebProtein function (UniProt)i. Useful information about the protein provided by UniProt. May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leu kemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 ...

Web28. dec 2024. · Development of colorectal cancer (CRC) is regulated by a series of genetic and microenvironmental alterations. Olfactomedin 4 (OLFM4) is a secreted glycoprotein … Web27. maj 2024. · OLFM4 is highly expressed in polymorphonuclear bone marrow-derived inhibitory cells in colitis and colorectal cancer, its expression levels and cell populations are positively correlated with the ...

WebNational Center for Biotechnology Information

Web19. nov 2015. · Loss of olfactomedin 4 (OLFM4) gene expression is associated with the progression of human prostate cancer, but its role and the molecular mechanisms … east brackenridge farm strathavenWeb28. sep 2010. · The OLFM4 gene was first identified by virtue of its high expression in colon cancer cells through analysis of Cancer Genome Anatomy Project data from the United States National Cancer Institute. The gene was originally cloned from human haematopoietic myeloid cells and mapped to chromosome 13q14.3 [].It consists of five … cuba safety indexWeb02. maj 2024. · Moreover, the cancer stem cell-like property of OLFM4 mediated by leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), known as an intestinal stem … east bracketWeb24. mar 2024. · OLFM4 is secreted and may be detected in serum and plasma therefore representing a good candidate CRC marker as previously suggested for gastric cancer [35, 36]. Sec24C is an essential coat protein II (COPII) component and COPII is involved in protein transports from the endoplasmic reticulum (ER). cuba safety for touristsWeb10. jan 2024. · Chemoresistance was observed by in vitro analysis of tumor cell lines with forced expression of OLFM4. In an assessment of tissue specimens from 80 patients with pancreatic cancer, Kaplan-Meier analysis showed that patients in the low OLFM4 expression group had a better survival rate than patients in the high OLFM4 expression … cubasch frankWeb20. feb 2024. · 并且有文献指出，OLFM4在与富含亮氨酸重复序列G蛋白偶联受体5（leucinerich-repeat-containing G-protein-coupled receptor 5，Lgr5）关联的结肠癌干细胞中有表达[14-15]，而Lgr5与肿瘤的恶性程度直接相关，这也进一步证明了OLFM4与结肠癌肿瘤的分期相关，或许可将OLFM4 作为结肠癌 ... cuba safety ratingWeb18. jul 2024. · Cancer molecular subtyping (describing cancer subtypes) is important not least because of its potential relevance to choice of treatment [1,2].In the case of Colon Cancer, classifications of colorectal cancers (CRC) can be subdivided into 3–6 subtypes, based on gene expression profiles [1,2,3,4].Alternatively, CRC has been shown to divide … cuba santa clara weather